import pandas as pd
import numpy as np

df = pd.DataFrame({'A#':[1,2,3], 'B#':[4,5,6], 'C#':[7,8,9]})
df
A# B# C#
1 4 7
2 5 8
3 6 9

Drop columns

df.drop(['B#', 'C#'], axis = 1)
#or
df.drop(columns=['B#', 'C#'])
A#
1
2
3

Drop rows

df.drop([0,1])
A# B# C#
3 6 9